Drug loading of foldable commercial intraocular lenses using supercritical impregnation
نویسندگان
چکیده
منابع مشابه
Supercritical Drug Impregnation onto Intraocular Lenses
Supercritical impregnation is an attractive “clean” alternative to conventional soaking into liquid process, using generally organic solvents. Impregnation process can be used for the development of controlled delivery systems that can be applied in pharmaceutical and medical fields. This work focuses on the preparation of controlled drug delivery systems for ophthalmic applications through sup...
متن کاملLate Opacification of Foldable Intraocular Lenses
Objective: To report opacification of hydrophilic acrylic and silicone foldable intraocular lenses (IOL). Designs: Case series. Participants: Five patients with IOL opacification. Results: We report five eyes of five patients with late opacification of the intraocular lens (IOL). Three patients had hydrophilic acrylic (SC60B-OUV-MDR, Inc), two had silicone IOL (Allergan SI30NB). Two out of the ...
متن کاملSupercritical Development of Sustained Drug Delivery Intraocular Lenses
Controlled drug delivery systems (DDS) are receiving an increasing interest since they enhance the drug efficacy by a target action in the body and a sustained release profile. Most of these DDS are polymer based where the polymer is biocompatible and sometimes biodegradable and acts as a reservoir or a matrix for the drug. Supercritical technologies have been demonstrated to be a clean and eff...
متن کاملSulcus Fixation of Foldable Intraocular Lenses Guided by Ultrasound Biomicroscopy
Background. To evaluate the clinical efficacy of suture fixation of foldable intraocular lens (IOL) in ciliary sulcus guided by ultrasound biomicroscopy (UBM). Methods. Thirty-five eyes of 32 cases needing suture fixation of foldable IOL in ciliary sulcus in our hospital were collected and divided into two groups: group A and group B. In group A, UBM was performed on 19 eyes of 17 cases before ...
متن کاملDrug-Eluting Intraocular Lenses
Notable advances in materials science and in surgical techniques make the management of cataract by replacement of the opaque crystalline with an intraocular lens (IOL), one of the most cost-effective interventions in current healthcare. The usefulness and safety of IOLs can be enhanced if they are endowed with the ability to load and to sustain drug release in the implantation site. Drug-eluti...
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ژورنال
عنوان ژورنال: International Journal of Pharmaceutics
سال: 2016
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2016.01.016